Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 10/20 | 0.36 |
| ▸ | LTB4R2 | Q9NPC1 | 4/20 | 0.36 |
| ▸ | AGTR2 | P50052 | 4/20 | 0.35 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.35 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9007516 | 0.83 | AGTR1 (0.37) | AGTR1LTB4R2AGTR2 | |
| SCHEMBL6111797 | 0.78 | AGTR1 (0.33) | AGTR1AGTR2 | |
| SCHEMBL6112511 | 0.77 | AGTR1 (0.33) | AGTR1LTB4R2AGTR2 | |
| SCHEMBL2052910 | 0.75 | AGTR1 (0.38) | AGTR1AGTR2 | |
| SCHEMBL9248296 | 0.74 | AGTR1 (0.48) | AGTR1LTB4R2AGTR2ABCC4ABCB11 | |
| SCHEMBL6953051 | 0.73 | HSD11B1 (0.47) | AGTR1AGTR2 | |
| SCHEMBL9541024 | 0.72 | AGTR1 (0.47) | AGTR1LTB4R2AGTR2ABCC4ABCB11 | |
| SCHEMBL8799310 | 0.72 | AGTR1 (0.47) | AGTR1AGTR2ABCC4ABCB11PDE3B | |
| SCHEMBL30929294 | 0.71 | AGTR1 (0.43) | AGTR1LTB4R2AGTR2ABCC4ABCB11 | |
| SCHEMBL6957300 | 0.71 | HSD11B1 (0.47) | AGTR1AGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612365-A | CARDIOVASCULAR DISORDERS AND COGNITIVE ACTIVATORS | HOECHST AKTIENGESELLSCHAFT (DE) | 1997-03-18 | — | — | US | disclosed |
| EP-0324377-A2 | Angiotensin II receptor blocking imidazoles and combinations thereof with diuretics and NSaids | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1989-07-19 | — | — | EP | disclosed |