Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 7/20 | 0.58 |
| ▸ | NPC1 | O15118 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.58 |
| ▸ | PKM | P14618 | 3/20 | 0.58 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.58 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.58 |
| ▸ | CDK5R1 | Q15078 | 2/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.56 |
| ▸ | LMNA | P02545 | 2/20 | 0.56 |
| ▸ | HTT | P42858 | 2/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CES2 | O00748 | 1/20 | 0.50 |
| ▸ | CES1 | P23141 | 1/20 | 0.50 |
| ▸ | F2 | P00734 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18983075 | 0.84 | KMT2A (0.61) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL68051 | 0.82 | CES2 (0.69) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL9723456 | 0.82 | CES2 (0.69) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL68050 | 0.82 | CES2 (0.69) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL30741457 | 0.82 | CES2 (0.69) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL18983080 | 0.80 | KMT2A (0.61) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL18983077 | 0.80 | KMT2A (0.61) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL3870748 | 0.80 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL29289270 | 0.79 | RAB9A (0.60) | RAB9ANPC1SMN1; SMN2PKMCDK5 | |
| SCHEMBL3347086 | 0.79 | RAB9A (0.68) | RAB9ANPC1SMN1; SMN2PKMCDK5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624090-B1 | REVERSAL OF MULTI-DRUG RESISTANCE BY TETRAARYLETHYLENES | MERRELL PHARMA INC (US) | 1996-09-18 | — | — | EP | claimed |
| US-5523304-A | Reversal of multi-drug resistance by tetraarylethylenes | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-04 | — | — | US | claimed |
| EP-0624090-A1 | REVERSAL OF MULTI-DRUG RESISTANCE BY TETRAARYLETHYLENES. | MERRELL DOW PHARMA (US) | 1994-11-17 | — | — | EP | claimed |
| WO-1993015733-A1 | REVERSAL OF MULTI-DRUG RESISTANCE BY TETRAARYLETHYLENES | MERRELL DOW PHARMACEUTICALS INC. (US) | 1993-08-19 | — | — | WO | claimed |
| US-5665780-A | DEACTIVATING P-GLYCOPROTEIN PUMP IN TUMORS; CANCER TREATMENT | MERRELL PHARMACEUTICALS INC. (US) | 1997-09-09 | — | — | US | disclosed |
| EP-0624090-B1 | REVERSAL OF MULTI-DRUG RESISTANCE BY TETRAARYLETHYLENES | MERRELL PHARMA INC (US) | 1996-09-18 | — | — | EP | disclosed |
| US-5523304-A | Reversal of multi-drug resistance by tetraarylethylenes | MERRELL PHARMACEUTICALS INC. (US) | 1996-06-04 | — | — | US | disclosed |