SCHEMBL8901213

SCHEMBL8901213

CC(=O)Nc1ccc(C(=O)OC(=O)C(F)(F)F)cc1-n1cc(-c2ccccc2)nc1N

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 7/20 0.38
KMT2A Q03164 4/20 0.38
MEN1 O00255 3/20 0.38
SMN1; SMN2 Q16637 3/20 0.38
NPC1 O15118 2/20 0.38
RAB9A P51151 2/20 0.38
LMNA P02545 2/20 0.38
GAA P10253 1/20 0.38
HTT P42858 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
ADORA3 P0DMS8 5/20 0.37
ADORA2A P29274 4/20 0.37
ADORA1 P30542 4/20 0.37
HPGD P15428 3/20 0.37
KDM4E B2RXH2 2/20 0.37
POLB P06746 1/20 0.37
NFKB1 P19838 1/20 0.37
NFKB2 Q00653 1/20 0.37
RELA Q04206 1/20 0.37
MAPT P10636 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8894617 0.92 ADORA3 (0.38) ALDH1A1KMT2AMEN1SMN1; SMN2NPC1
SCHEMBL8891105 0.91 ADORA3 (0.39) ALDH1A1KMT2AMEN1SMN1; SMN2NPC1
SCHEMBL8902589 0.87 KMT2A (0.39) ALDH1A1KMT2AMEN1SMN1; SMN2NPC1
Trifluoroacetic Acid SCHEMBL8901207 0.87 ALDH1A1 (0.40) ALDH1A1KMT2AMEN1SMN1; SMN2NPC1
SCHEMBL8892913 0.86 ADORA2A (0.41) ALDH1A1KMT2AMEN1LMNAGAA
SCHEMBL8900955 0.86 SCN3A (0.41) ALDH1A1KMT2AMEN1SMN1; SMN2NPC1
SCHEMBL8901022 0.84 ADORA3 (0.44) ALDH1A1KMT2AMEN1SMN1; SMN2NPC1
Trifluoroacetic Acid SCHEMBL8894608 0.79 ADORA3 (0.40) ALDH1A1KMT2AMEN1SMN1; SMN2NPC1
SCHEMBL8901564 0.79 ALDH1A1 (0.34) ALDH1A1KMT2ALMNAHPGDCYP2C19
Trifluoroacetic Acid SCHEMBL8891099 0.79 ADORA3 (0.41) ALDH1A1KMT2AMEN1SMN1; SMN2RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997033872-A1 ANTI-VIRAL 4-ACYLAMINO-3-[IMIDAZOL-I-YL]-BENZOIC ACID DERIVATIVES BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 1997-09-18 WO disclosed