SCHEMBL8901564

SCHEMBL8901564

CC(=O)Nc1ccc(C(=O)OC(=O)C(F)(F)F)cc1-n1ccnc1N

nearest known ligand 0.35

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.34
PIK3CA P42336 1/20 0.33
MAPK14 Q16539 1/20 0.33
HDAC1 Q13547 3/20 0.33
TLR2 O60603 1/20 0.32
TLR1 Q15399 1/20 0.32
KMT2A Q03164 2/20 0.32
HDAC6 Q9UBN7 1/20 0.32
CYP1A2 P05177 2/20 0.32
CYP2C9 P11712 1/20 0.32
CYP2C19 P33261 1/20 0.32
LMNA P02545 1/20 0.32
HPGD P15428 1/20 0.32
ABL1 P00519 1/20 0.32
F2 P00734 1/20 0.31
F10 P00742 1/20 0.31
HDAC3 O15379 1/20 0.31
HDAC2 Q92769 1/20 0.31
NCOR2 Q9Y618 1/20 0.31
BRD4 O60885 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8900647 0.90 MAPT (0.35) ALDH1A1MAPK14TLR2TLR1CYP1A2
SCHEMBL8902205 0.87 ALPG (0.35) ALDH1A1TLR2TLR1KMT2ACYP1A2
SCHEMBL8901135 0.84 ALOX15 (0.40) ALDH1A1MAPK14HDAC1KMT2ABRD4
Trifluoroacetic Acid SCHEMBL8901557 0.84 NEU3 (0.42) ALDH1A1PIK3CAMAPK14HDAC1KMT2A
SCHEMBL8900474 0.81 NEU3 (0.47) ALDH1A1MAPK14HDAC1KMT2AHDAC6
SCHEMBL8901213 0.79 ALDH1A1 (0.38) ALDH1A1HDAC1KMT2ACYP2C19LMNA
SCHEMBL8894617 0.78 ADORA3 (0.38) ALDH1A1PIK3CAKMT2ALMNAHPGD
SCHEMBL8891105 0.77 ADORA3 (0.39) ALDH1A1PIK3CAHDAC1KMT2ALMNA
SCHEMBL8892913 0.76 ADORA2A (0.41) ALDH1A1KMT2ACYP1A2CYP2C19LMNA
Trifluoroacetic Acid SCHEMBL8900639 0.75 MAPT (0.38) ALDH1A1MAPK14KMT2AHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997033872-A1 ANTI-VIRAL 4-ACYLAMINO-3-[IMIDAZOL-I-YL]-BENZOIC ACID DERIVATIVES BIOTA SCIENTIFIC MANAGEMENT PTY. LTD. (AU) 1997-09-18 WO disclosed