Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 2/20 | 0.47 |
| ▸ | HTR1A | P08908 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 2/20 | 0.45 |
| ▸ | RET | P07949 | 1/20 | 0.45 |
| ▸ | ADRA2B | P18089 | 2/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 2/20 | 0.44 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.44 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.44 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.43 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.43 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.42 |
| ▸ | BCHE | P06276 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | DRD2 | P14416 | 1/20 | 0.41 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 2/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL62360 | 0.85 | HTR6 (0.59) | HTR6HTR2ARETADRA2BADRA2C | |
| SCHEMBL61507 | 0.85 | HTR6 (0.59) | HTR6HTR2ARETADRA2BADRA2C | |
| SCHEMBL29681415 | 0.85 | HTR6 (0.59) | HTR6HTR2ARETADRA2BADRA2C | |
| SCHEMBL10468985 | 0.84 | HTR1A (0.47) | HTR6HTR1AADRA2BADRA2CADRA1A | |
| Hydrochloric Acid SCHEMBL15818880 | 0.84 | HTR6 (0.57) | HTR6HTR2ARETADRA2BADRA2C | |
| SCHEMBL7864500 | 0.75 | ALDH1A1 (0.52) | HTR6 | |
| SCHEMBL29547256 | 0.75 | BCHE (0.56) | HTR6HTR1AADRA2BADRA2CADRA1A | |
| SCHEMBL4431417 | 0.75 | BCHE (0.56) | HTR6HTR1AADRA2BADRA2CADRA1A | |
| SCHEMBL643387 | 0.75 | HTR6 (0.56) | HTR6HTR2ARET | |
| SCHEMBL9115029 | 0.75 | HTR6 (0.54) | HTR6HTR1AADRA2BADRA2CADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0807101-A1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1997-11-19 | — | — | EP | disclosed |
| WO-1996023760-A1 | 2-AMINOINDANS AS SELECTIVE DOPAMINE D3 LIGANDS | PHARMACIA & UPJOHN COMPANY (US) | 1996-08-08 | — | — | WO | disclosed |