Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 2/20 | 0.47 |
| ▸ | HTR6 | P50406 | 2/20 | 0.45 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.45 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.45 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | BCHE | P06276 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.44 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.43 |
| ▸ | MAOA | P21397 | 2/20 | 0.42 |
| ▸ | MAOB | P27338 | 2/20 | 0.42 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8901289 | 0.84 | HTR6 (0.47) | HTR1AHTR6MTNR1AMTNR1BPDPK1 | |
| SCHEMBL10469040 | 0.81 | MTNR1A (0.46) | HTR6MTNR1AMTNR1BALDH1A1SMN1; SMN2 | |
| SCHEMBL7864500 | 0.80 | ALDH1A1 (0.52) | HTR6ALDH1A1 | |
| SCHEMBL10468562 | 0.80 | PDPK1 (0.55) | HTR6MTNR1AMTNR1BPDPK1BCHE | |
| SCHEMBL9627796 | 0.79 | NQO2 (0.57) | HTR1AMTNR1AMTNR1BCYP2D6DRD2 | |
| SCHEMBL11437064 | 0.79 | BCHE (0.41) | HTR6MTNR1AMTNR1BPDPK1ALDH1A1 | |
| SCHEMBL29547256 | 0.78 | BCHE (0.56) | HTR1AHTR6MTNR1AMTNR1BPDPK1 | |
| SCHEMBL4431417 | 0.78 | BCHE (0.56) | HTR1AHTR6MTNR1AMTNR1BPDPK1 | |
| SCHEMBL23023167 | 0.77 | HTR2A (0.58) | HTR6MTNR1AMTNR1BALDH1A1DRD2 | |
| SCHEMBL19828084 | 0.77 | POLB (0.43) | HTR1ACYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4957914-A | ANTIDEPRESSANTS, ANXIOLYTICS, HYPOTENSIVE AGENTS | SYNTEX (U.S.A.) INC. (US) | 1990-09-18 | — | — | US | disclosed |