SCHEMBL8901336

SCHEMBL8901336

CC(C(=O)O)n1c(=O)[nH]c(=O)c2c(Br)cc(Br)cc21

nearest known ligand 0.37

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
GRIA1 P42261 1/20 0.35
GRIA2 P42262 1/20 0.35
GRIA4 P48058 1/20 0.35
GRIK5 Q16478 1/20 0.35
KMT2A Q03164 1/20 0.32
B3GNT2 Q9NY97 1/20 0.32
GPR17 Q13304 1/20 0.31
PTGDR2 Q9Y5Y4 1/20 0.30
POLB P06746 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8907357 0.76 CA12 (0.38) GRIA1GRIA2GRIA4GRIK5KMT2A
SCHEMBL8901340 0.68 KDM4E (0.40) KMT2A
SCHEMBL6526383 0.65 CSNK2A2 (0.37) GRIA1GRIA2GRIA4GRIK5KMT2A
SCHEMBL27524563 0.65 CSNK2A2 (0.37) GRIA1GRIA2GRIA4GRIK5KMT2A
SCHEMBL639581 0.64 DAO (0.55) B3GNT2PTGDR2
SCHEMBL15486713 0.61 DNMT1 (0.45) KMT2APTGDR2
SCHEMBL7336986 0.61 KDM4E (0.45) KMT2A
SCHEMBL29251525 0.60 APEX1 (0.35) KMT2AB3GNT2
SCHEMBL29150265 0.59 POLB (0.34) POLB
SCHEMBL18954632 0.59 PARK7 (0.43) KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997002254-A1 QUINAZOLINE DERIVATIVES FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1997-01-23 WO disclosed