SCHEMBL8901644

SCHEMBL8901644

CCOC(=O)C1Cc2c(OC)ccc(OC)c2CO1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CTDSP1 Q9GZU7 1/20 0.44
TDP1 Q9NUW8 1/20 0.44
CA12 O43570 2/20 0.42
CA1 P00915 2/20 0.42
CA2 P00918 2/20 0.42
CA9 Q16790 2/20 0.42
ALDH1A1 P00352 6/20 0.40
KDM4E B2RXH2 4/20 0.40
KMT2A Q03164 2/20 0.40
PDE4A P27815 1/20 0.39
PDE4B Q07343 1/20 0.39
PDE4C Q08493 1/20 0.39
PDE4D Q08499 1/20 0.39
ADRA1A P35348 1/20 0.39
MEN1 O00255 1/20 0.39
ATM Q13315 1/20 0.39
CYP4F2 P78329 1/20 0.38
CYP4A11 Q02928 1/20 0.38
L3MBTL1 Q9Y468 2/20 0.38
HPGD P15428 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8527142 0.85 MIF (0.46) TDP1ALDH1A1ADRA1AHPGDHTT
SCHEMBL8529815 0.82 ADRA1A (0.46) ALDH1A1KDM4EADRA1AHPGDCYP1A2
SCHEMBL8902148 0.81 KDM4E (0.38) CTDSP1TDP1CA12CA1CA2
SCHEMBL8527470 0.81 CYP1A2 (0.47) CA12CA1CA2CA9ALDH1A1
SCHEMBL8527137 0.81 MIF (0.45) ALDH1A1KDM4EADRA1AHPGDCYP1A2
SCHEMBL8527222 0.81 ADRA1A (0.39) ALDH1A1KDM4EKMT2APDE4BADRA1A
SCHEMBL8527872 0.79 ADRA1A (0.40) ALDH1A1ADRA1AHPGDCYP1A2
SCHEMBL8533392 0.78 ADRA1A (0.42) ALDH1A1ADRA1AHPGDCYP1A2
SCHEMBL8901817 0.78 HTT (0.48) TDP1ALDH1A1ATML3MBTL1HPGD
SCHEMBL8531328 0.77 ADRA1A (0.41) ALDH1A1KDM4EADRA1AHPGDCYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5593970-A ANTITUMOR AND ANTCARCINOGENIC AGENTS; TRETMENT OF CANCEROUS BONE MARROW BEFORE REGRAFTING BIOCHEM PHARMA INC. (CA) 1997-01-14 US claimed
US-5593970-A ANTITUMOR AND ANTCARCINOGENIC AGENTS; TRETMENT OF CANCEROUS BONE MARROW BEFORE REGRAFTING BIOCHEM PHARMA INC. (CA) 1997-01-14 US disclosed
EP-0533744-A1 HETEROCYCLIC ANTHRACYCLIONE AND ANTHRACYCLINE ANALOGS BIOCHEM PHARMA INC. (CA) 1993-03-31 EP disclosed
WO-1991019725-A2 HETEROCYCLIC ANTHRACYCLIONE AND ANTHRACYCLINE ANALOGS BIOCHEM PHARMA INC. (CA) 1991-12-26 WO disclosed