Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.67 |
| ▸ | GAA | P10253 | 1/20 | 0.67 |
| ▸ | ATM | Q13315 | 1/20 | 0.60 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.51 |
| ▸ | MEN1 | O00255 | 4/20 | 0.51 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.51 |
| ▸ | HTR2C | P28335 | 2/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.39 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.39 |
| ▸ | HPN | P05981 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4919831 | 0.81 | ATM (0.69) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL4919848 | 0.81 | ATM (0.69) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL4919841 | 0.81 | ATM (0.69) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL5748309 | 0.80 | RAB9A (0.71) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL9024919 | 0.80 | GAA (1.00) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL5748304 | 0.80 | RAB9A (0.71) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL5748307 | 0.80 | RAB9A (0.71) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL6098746 | 0.76 | SMN1; SMN2 (0.74) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL7898746 | 0.76 | SMN1; SMN2 (0.74) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL7898749 | 0.76 | SMN1; SMN2 (0.74) | RAB9AGAAATMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5703240-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-12-30 | — | — | US | disclosed |
| EP-0720609-A1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 1996-07-10 | — | — | EP | disclosed |
| WO-1995008549-A1 | 3-(5-TETRAZOLYL-BENZYL)AMINO-PIPERIDINE DERIVATIVES AND ANTAGONISTS OF TACHYKININS | GLAXO GROUP LIMITED (GB) | 1995-03-30 | — | — | WO | disclosed |