Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 1.00 |
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | POLB | P06746 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.36 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.36 |
| ▸ | RECQL | P46063 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748309 | 0.83 | RAB9A (0.71) | GAARAB9AATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL5748307 | 0.83 | RAB9A (0.71) | GAARAB9AATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL5748304 | 0.83 | RAB9A (0.71) | GAARAB9AATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL8901705 | 0.80 | RAB9A (0.67) | GAARAB9AATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL7898749 | 0.80 | SMN1; SMN2 (0.74) | GAARAB9AATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL7898746 | 0.80 | SMN1; SMN2 (0.74) | GAARAB9AATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL6098746 | 0.80 | SMN1; SMN2 (0.74) | GAARAB9AATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL6099592 | 0.77 | ALDH1A1 (0.74) | GAARAB9AATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL6099600 | 0.77 | ALDH1A1 (0.74) | GAARAB9AATMSMN1; SMN2ALDH1A1 | |
| SCHEMBL6099597 | 0.77 | ALDH1A1 (0.74) | GAARAB9AATMSMN1; SMN2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0600952-B1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK SHARP & DOHME (GB) | 1996-04-17 | — | — | EP | disclosed |
| US-5459270-A | Tachykinin antagonist for central nervous systum disorders and cardiovascular disorders | MERCK SHARP & DOHME LIMITED (GB) | 1995-10-17 | — | — | US | disclosed |
| EP-0600952-A1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM. | MERCK SHARP & DOHME (GB) | 1994-06-15 | — | — | EP | disclosed |
| WO-1993004040-A1 | AZACYCLIC COMPOUNDS, PROCESSES FOR THEIR PREPARATION AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | MERCK SHARP & DOHME LIMITED (GB) | 1993-03-04 | — | — | WO | disclosed |
| EP-0528495-A1 | Azacyclic compounds, processes for their preparation and pharmaceutical compositions containing them | MERCK SHARP & DOHME LTD. (GB) | 1993-02-24 | — | — | EP | disclosed |