Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 1/20 | 0.71 |
| ▸ | GAA | P10253 | 1/20 | 0.71 |
| ▸ | ATM | Q13315 | 1/20 | 0.67 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.57 |
| ▸ | MEN1 | O00255 | 3/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.48 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.47 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.47 |
| ▸ | HTR2C | P28335 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5748304 | 1.00 | RAB9A (0.71) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL5748309 | 1.00 | RAB9A (0.71) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL9024919 | 0.83 | GAA (1.00) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL8901705 | 0.80 | RAB9A (0.67) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL6098746 | 0.80 | SMN1; SMN2 (0.74) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL7898746 | 0.80 | SMN1; SMN2 (0.74) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL7898749 | 0.80 | SMN1; SMN2 (0.74) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL9025236 | 0.77 | ALDH1A1 (1.00) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL4919841 | 0.77 | ATM (0.69) | RAB9AGAAATMALDH1A1SMN1; SMN2 | |
| SCHEMBL4919848 | 0.77 | ATM (0.69) | RAB9AGAAATMALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1638935-A1 | NK1 ANTAGONIST | Pfizer Products Inc. (US) | 2006-03-29 | — | — | EP | disclosed |
| US-20050043354-A1 | NK1 antagonist | PFIZER INC | 2005-02-24 | — | — | US | disclosed |
| WO-2004110996-A1 | NK1 ANTAGONIST | PFIZER PRODUCTS INC. (US) | 2004-12-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050043354-A1 | NK1 antagonist | TACR2, TACR1, TAC3 | RAB9A 4047/4885GAA 2068/4885ATM 4396/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.