SCHEMBL8901773

SCHEMBL8901773

CCCc1nc(C)c(C(O)=S)n1Cc1ccc(-c2ccccc2S(=O)(=O)NC(=O)OCc2ccccc2)cc1

nearest known ligand 0.63

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AGTR1 P30556 5/20 0.59
AGTR2 P50052 5/20 0.59

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8971097 0.95 AGTR2 (0.60) AGTR1AGTR2
SCHEMBL8902817 0.94 AGTR1 (0.59) AGTR1AGTR2
SCHEMBL8902412 0.93 AGTR1 (0.59) AGTR1AGTR2
SCHEMBL8903314 0.92 AGTR2 (0.62) AGTR1AGTR2
SCHEMBL8969870 0.89 AGTR2 (0.58) AGTR2
SCHEMBL8902745 0.88 AGTR1 (0.57) AGTR1AGTR2
SCHEMBL8971011 0.86 AGTR2 (0.57) AGTR1AGTR2
SCHEMBL8899458 0.85 AGTR2 (0.73) AGTR1AGTR2
SCHEMBL7022844 0.85 AGTR1 (0.76) AGTR1AGTR2
SCHEMBL8970010 0.83 AGTR2 (0.60) AGTR1AGTR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5604251-A Imidazole derivatives with a biphenylsulfonylurea or biphenylsulfonylurethane side chain and their use as angitensin II receptors HOECHST AKTIENGESELLSCHAFT (DE) 1997-02-18 US disclosed