Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Sulfaquinoxaline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.64 |
| ▸ | SLC19A2 | O60779 | 1/20 | 0.64 |
| ▸ | USP2 | O75604 | 1/20 | 0.64 |
| ▸ | CASP1 | P29466 | 1/20 | 0.64 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.64 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.55 |
| ▸ | ATIC | P31939 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.40 |
| ▸ | MEN1 | O00255 | 8/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Amprolium Ion SCHEMBL362893 | 0.80 | KDM4E (0.98) | KDM4ELMNASLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL28047744 | 0.80 | KDM4E (0.98) | KDM4ELMNASLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL29910331 | 0.80 | KDM4E (0.98) | KDM4ELMNASLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL29737311 | 0.79 | KDM4E (1.00) | KDM4ELMNASLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL363586 | 0.79 | KDM4E (0.95) | KDM4ELMNASLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL29387363 | 0.79 | KDM4E (0.95) | KDM4ELMNASLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL204024 | 0.78 | KDM4E (0.98) | KDM4ELMNASLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL20659804 | 0.78 | KDM4E (0.98) | KDM4ELMNASLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL1571391 | 0.75 | KDM4E (0.85) | KDM4ELMNASLC19A2USP2CASP1 | |
| Amprolium Ion SCHEMBL7107461 | 0.74 | KDM4E (0.83) | KDM4ELMNASLC19A2USP2CASP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5646135-A | ADMINISTERING, IN SEQUENCE, TWO DIFFERENT ANTICOCCIDIAL COMPOUNDS TO POULTRY | MERCK & CO., INC. (US) | 1997-07-08 | — | — | US | disclosed |