Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.39 |
| ▸ | ACE | P12821 | 3/20 | 0.38 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.38 |
| ▸ | MME | P08473 | 6/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | ECE1 | P42892 | 1/20 | 0.36 |
| ▸ | BLM | P54132 | 1/20 | 0.36 |
| ▸ | NPEPPS | P55786 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.35 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.34 |
| ▸ | TNKS | O95271 | 1/20 | 0.34 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGA5 | P08648 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7745199 | 0.76 | ACE (0.47) | MAPK1ACEMMEALDH1A1HPGD | |
| SCHEMBL2028236 | 0.76 | ACE (0.47) | MAPK1ACEMMEALDH1A1HPGD | |
| SCHEMBL8595093 | 0.70 | ACE (0.51) | MAPK1ACEMMEALDH1A1HPGD | |
| SCHEMBL9262225 | 0.68 | GAA (0.55) | MAPK1ALDH1A1MEN1MAPTKMT2A | |
| SCHEMBL9067648 | 0.67 | ACE (0.46) | MAPK1ACEMMEALDH1A1HPGD | |
| SCHEMBL8904453 | 0.67 | SLC1A2 (0.40) | MAPK1ACEKEAP1MMEALDH1A1 | |
| SCHEMBL10720961 | 0.65 | KMT2A (0.38) | MAPK1ACEMMEALDH1A1HPGD | |
| SCHEMBL9067650 | 0.64 | ACE (0.40) | MAPK1ACEMMEALDH1A1HPGD | |
| SCHEMBL3211065 | 0.64 | NPC1 (0.54) | MAPK1KEAP1ALDH1A1HPGDHSD17B10 | |
| SCHEMBL10363565 | 0.64 | ALDH1A1 (0.55) | MAPK1ACEMMEALDH1A1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5681927-A | COMPLEXES | NEORX CORPORATION (US) | 1997-10-28 | — | — | US | disclosed |
| EP-0284071-B1 | Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy | NEORX CORP (US) | 1994-06-08 | — | — | EP | disclosed |
| US-5091514-A | Antitumor, anticarcinogenic agents | NEORX CORPORATION (US) | 1992-02-25 | — | — | US | disclosed |
| US-4965392-A | DIAGNOSIS, RADIOTHERAPY OF TUMORS | NEORX CORPORATION (US) | 1990-10-23 | — | — | US | disclosed |
| EP-0284071-A2 | Metal-radionuclide-labeled proteins and glycoproteins for diagnosis and therapy | NEORX CORPORATION (US) | 1988-09-28 | — | — | EP | disclosed |