SCHEMBL8905440

SCHEMBL8905440

CNC(=O)C(Cc1ccccc1)NC(=O)C(C)(Cc1ccc2ccccc2c1)NC

nearest known ligand 0.58

Predicted protein targets (top 10)

geneUniProtsupporting neighboursconfidence
FCER2 P06734 2/20 0.58
MMP2 P08253 11/20 0.49
MMP9 P14780 5/20 0.49
MMP8 P22894 3/20 0.49
MMP1 P03956 8/20 0.48
MMP3 P08254 7/20 0.48
CTSB P07858 2/20 0.48
CTSS P25774 2/20 0.48
CTSK P43235 1/20 0.48
CTSL P07711 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8906170 0.81 CYP1A2 (0.46) FCER2CTSBCTSSCTSKCTSL
SCHEMBL762206 0.81 FCER2 (0.57) FCER2MMP2MMP9MMP8MMP1
SCHEMBL7771309 0.79 GHSR (0.45) FCER2MMP9MMP8
SCHEMBL5966507 0.75 CTSS (0.74) FCER2MMP2MMP9MMP8CTSB
SCHEMBL5557866 0.75 CTSS (0.74) FCER2MMP2MMP9MMP8CTSB
SCHEMBL8206981 0.74 FCER2 (0.60) FCER2MMP2MMP9MMP8CTSB
SCHEMBL14748080 0.74 FCER2 (0.55) FCER2MMP2MMP9MMP8CTSB
SCHEMBL14527604 0.74 CHRNB2 (0.55)
SCHEMBL6851903 0.73 FCER2 (1.00) FCER2MMP2MMP9MMP8MMP1
SCHEMBL7650106 0.72 FCER2 (0.59) FCER2MMP2MMP9MMP8MMP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-1997023508-A1 COMPOUNDS WITH GROWTH HORMONE RELEASING PROPERTIES NOVO NORDISK A/S (DK) 1997-07-03 WO disclosed