SCHEMBL8905699

SCHEMBL8905699

CC(=O)Nc1c(I)c(C(N)=O)c(I)c(C(=O)NCC(O)CO)c1I

nearest known ligand 0.55

Predicted protein targets (top 14)

geneUniProtsupporting neighboursconfidence
LMNA P02545 6/20 0.55
CYP2C19 P33261 1/20 0.55
HIF1A Q16665 1/20 0.55
SMN1; SMN2 Q16637 1/20 0.45
EGFR P00533 1/20 0.36
SRC P12931 1/20 0.36
MAP2K1 Q02750 7/20 0.35
MAP2K2 P36507 2/20 0.32
PRKCZ Q05513 1/20 0.32
IARS2 Q9NSE4 1/20 0.32
CA2 P00918 1/20 0.32
KDM4E B2RXH2 1/20 0.30
ALDH1A1 P00352 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL619944 0.95 LMNA (0.60) LMNACYP2C19HIF1ASMN1; SMN2EGFR
SCHEMBL1557465 0.93 LMNA (0.59) LMNACYP2C19HIF1ASMN1; SMN2EGFR
SCHEMBL14769256 0.92 LMNA (0.56) LMNACYP2C19HIF1ASMN1; SMN2EGFR
SCHEMBL8373468 0.91 LMNA (0.51) LMNACYP2C19HIF1ASMN1; SMN2EGFR
SCHEMBL8378015 0.91 LMNA (0.56) LMNACYP2C19HIF1ASMN1; SMN2EGFR
SCHEMBL9189596 0.91 LMNA (0.56) LMNACYP2C19HIF1ASMN1; SMN2EGFR
SCHEMBL9293089 0.90 LMNA (0.47) LMNACYP2C19HIF1ASMN1; SMN2EGFR
SCHEMBL8905505 0.90 SMN1; SMN2 (0.57) LMNACYP2C19HIF1ASMN1; SMN2EGFR
SCHEMBL9237406 0.90 LMNA (0.55) LMNACYP2C19HIF1ASMN1; SMN2EGFR
Hydrochloric Acid SCHEMBL10429710 0.88 SMN1; SMN2 (0.56) LMNACYP2C19HIF1ASMN1; SMN2EGFR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-116421744-A Absorbable medical hydrogel and preparation method thereof 杭州融华再生医学科技有限公司 2023-07-14 CN claimed
CN-116421744-B Absorbable medical hydrogel and preparation method thereof 杭州融华再生医学科技有限公司 2024-02-09 CN disclosed
CN-116421744-A Absorbable medical hydrogel and preparation method thereof 杭州融华再生医学科技有限公司 2023-07-14 CN disclosed
US-5698739-A RADIOLOGY SCHERING AKTIENGESELLSCHAFT (DE) 1997-12-16 US disclosed
EP-0406992-B1 New non-ionic carboxamide contrast agent SCHERING AG (DE) 1995-03-15 EP disclosed
WO-1993012071-A1 5,5'-/(1,3-PROPANEDIYL) BIS-/IMINO(2-OXO-2,1-ETHANEDIYL)ACETYLIMINO/BIS(2,4,6-TRIIODO-1,3-BENZENEDICARBOXYAMIDES), AND CONTRAST MEDIA CONTAINING THEM BRACCO S.P.A. (IT) 1993-06-24 WO disclosed
EP-0406992-A2 New non-ionic carboxamide contrast agent SCHERING AKTIENGESELLSCHAFT (DE) 1991-01-09 EP disclosed
EP-0233249-A4 NON-IONIC POLYOL CONTRAST MEDIA FROM IONIC CONTRAST MEDIA. COOK MANAGING INC (US) 1988-10-06 EP disclosed
EP-0233249-A1 NON-IONIC POLYOL CONTRAST MEDIA FROM IONIC CONTRAST MEDIA. COOK MANAGING INC (US) 1987-08-26 EP disclosed
WO-1987000757-A1 NON-IONIC POLYOL CONTRAST MEDIA FROM IONIC CONTRAST MEDIA COOK IMAGING, INC. (US) 1987-02-12 WO disclosed