Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 19/20 | 0.51 |
| ▸ | DRD2 | P14416 | 13/20 | 0.51 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11479739 | 0.88 | SIGMAR1 (0.42) | SIGMAR1DRD2 | |
| SCHEMBL11490886 | 0.82 | FFAR1 (0.51) | SIGMAR1DRD2 | |
| SCHEMBL16451470 | 0.78 | SIGMAR1 (0.40) | SIGMAR1DRD2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL8700031 | 0.75 | SIGMAR1 (0.53) | SIGMAR1DRD2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL27468872 | 0.72 | SIGMAR1 (0.57) | SIGMAR1DRD2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL357523 | 0.71 | SIGMAR1 (0.49) | SIGMAR1DRD2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL11485028 | 0.68 | SIGMAR1 (0.46) | SIGMAR1DRD2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL28441240 | 0.66 | SIGMAR1 (0.37) | SIGMAR1DRD2 | |
| SCHEMBL37303 | 0.64 | CFTR (0.44) | SIGMAR1DRD2GRIN2DGRIN3BGRIN1 | |
| SCHEMBL6341038 | 0.64 | CFTR (0.44) | SIGMAR1DRD2GRIN2DGRIN3BGRIN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4038289-A | FLUORESCENT LABELING, BIOLOGICAL | HOFFMANN-LA ROCHE INC. (US) | 1977-07-26 | — | — | US | claimed |
| US-5698585-A | FOR SENILE CATARACT CAUSED BY OXIDATION DISORDER; VISION DEFECTS | KIKKOMAN CORPORATION (JP) | 1997-12-16 | — | — | US | disclosed |
| EP-0737476-A2 | A pharmaceutical preparation containing a 3-(2H)-furanone derivative for prevention and/or treatment of cataracts | KIKKOMAN CORPORATION (JP) | 1996-10-16 | — | — | EP | disclosed |
| US-4238589-A | A 1-TERT-AMINO-4-PHENYL-2-(CARBOXY-SUBSTITUTED PHENYL)-1-BUTEN-3,4-DIONE; CHEMICAL INTERMEDIATE | HOFFMANN-LA ROCHE INC. (US) | 1980-12-09 | — | — | US | disclosed |
| US-4045487-A | FLUOROGENIC REAGENTS | HOFFMANN-LA ROCHE INC. (US) | 1977-08-30 | — | — | US | disclosed |
| US-4038289-A | FLUORESCENT LABELING, BIOLOGICAL | HOFFMANN-LA ROCHE INC. (US) | 1977-07-26 | — | — | US | disclosed |