Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.38 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.38 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.38 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 2/20 | 0.38 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | THRB | P10828 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | ALPG | P10696 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.35 |
| ▸ | KDM4A | O75164 | 1/20 | 0.33 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905554 | 0.88 | LMNA (0.45) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8904746 | 0.86 | NPSR1 (0.41) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL9031112 | 0.86 | CXCL8 (0.40) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8905800 | 0.85 | AKR1B1 (0.54) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8905641 | 0.84 | PLK1 (0.40) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8905896 | 0.84 | PTGS2 (0.41) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8905930 | 0.84 | AKR1B1 (0.41) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8904190 | 0.84 | AKR1B1 (0.41) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8904844 | 0.83 | AKR1B1 (0.43) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8904821 | 0.83 | CXCL8 (0.41) | CXCL8AKR1B1PTGS1PTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5622948-A | ANALGESICS | SYNTEX (U.S.A.) INC. (US) | 1997-04-22 | — | — | US | disclosed |
| EP-0714895-A1 | Pyrrole derivatives | F. Hoffmann-La Roche AG (CH) | 1996-06-05 | — | — | EP | disclosed |