SCHEMBL8906008

SCHEMBL8906008

O=C1c2ccccc2C(=O)N1CC1CCc2ccccc2N1

nearest known ligand 0.47

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MTNR1A P48039 3/20 0.47
ALDH1A1 P00352 4/20 0.43
CYP2C9 P11712 3/20 0.43
CYP2C19 P33261 3/20 0.43
KDM4E B2RXH2 2/20 0.43
CYP1A2 P05177 1/20 0.43
GLA P06280 1/20 0.42
HTR1A P08908 1/20 0.41
HTR7 P34969 1/20 0.41
DRD3 P35462 1/20 0.41
NPSR1 Q6W5P4 2/20 0.40
ACHE P22303 1/20 0.40
CYP3A4 P08684 2/20 0.40
MEN1 O00255 1/20 0.40
MAPT P10636 1/20 0.40
KMT2A Q03164 1/20 0.40
KEAP1 Q14145 4/20 0.40
NPC1 O15118 1/20 0.40
RAB9A P51151 1/20 0.40
NFE2L2 Q16236 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8905140 0.85 CYP2C9 (0.42) ALDH1A1CYP2C9CYP2C19KDM4ECYP1A2
SCHEMBL15254389 0.82 CYP1A2 (0.48) ALDH1A1CYP2C9CYP2C19KDM4ECYP1A2
SCHEMBL15254386 0.82 CYP1A2 (0.48) ALDH1A1CYP2C9CYP2C19KDM4ECYP1A2
SCHEMBL6687679 0.77 CYP1A2 (0.47) ALDH1A1CYP2C9CYP2C19CYP1A2ACHE
SCHEMBL16585521 0.76 PDK1 (0.39) CYP2C9CYP2C19CYP1A2
SCHEMBL7149457 0.75 MTNR1A (0.56) MTNR1AHTR1ADRD3MAPTNPC1
SCHEMBL7951734 0.74 MTNR1A (0.55) MTNR1AMAPTNPC1
SCHEMBL31199115 0.72 DRD2 (0.43) ALDH1A1CYP2C9CYP2C19CYP1A2GLA
SCHEMBL32668882 0.72 DRD2 (0.43) ALDH1A1CYP2C9CYP2C19CYP1A2GLA
SCHEMBL5364032 0.72 DRD2 (0.43) ALDH1A1CYP2C9CYP2C19CYP1A2GLA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2015040424-A1 TETRAHYDROISOQUINOLINE COMPOUNDS AND THEIR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS VERNALIS (R&D) LIMITED (GB) 2015-03-26 WO disclosed
WO-2015040424-A1 TETRAHYDROISOQUINOLINE COMPOUNDS AND THEIR USE AS PYRUVATE DEHYDROGENASE KINASE INHIBITORS VERNALIS (R&D) LIMITED (GB) 2015-03-26 WO disclosed
US-5616586-A Tricyclic quinoxalinediones SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1997-04-01 US disclosed
EP-0642508-A1 TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1995-03-15 EP disclosed
WO-1993008188-A1 TRICYCLIC QUINOXALINEDIONES AS GLUTAMATE RECEPTOR ANTAGONISTS SUMITOMO PHARMACEUTICALS COMPANY, LIMITED (JP) 1993-04-29 WO disclosed