Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 8/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | TYR | P14679 | 1/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | THRA | P10827 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 1/20 | 0.32 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.32 |
| ▸ | RARA | P10276 | 1/20 | 0.32 |
| ▸ | RARB | P10826 | 1/20 | 0.32 |
| ▸ | RARG | P13631 | 1/20 | 0.32 |
| ▸ | RXRB | P28702 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905381 | 1.00 | RXRA (0.40) | RXRAMEN1TP53CYP3A4ALOX5 | |
| SCHEMBL8906033 | 0.85 | RXRA (0.40) | RXRAMEN1TP53CYP3A4ALOX5 | |
| SCHEMBL7143696 | 0.85 | RXRA (0.43) | RXRAMEN1TP53CYP3A4ALOX5 | |
| SCHEMBL7143276 | 0.84 | RXRA (0.43) | RXRAPPARGNR1H3RARARARB | |
| SCHEMBL8906014 | 0.81 | RXRA (0.44) | RXRAMEN1KMT2APPARGNR1H3 | |
| SCHEMBL4234613 | 0.81 | ALOX5 (0.43) | MEN1TP53CYP3A4ALOX5MAPT | |
| SCHEMBL7525439 | 0.81 | ALOX5 (0.43) | MEN1TP53CYP3A4ALOX5MAPT | |
| SCHEMBL30102585 | 0.81 | ALOX5 (0.43) | MEN1TP53CYP3A4ALOX5MAPT | |
| SCHEMBL12802062 | 0.77 | ALOX5 (0.41) | MEN1TP53CYP3A4ALOX5MAPT | |
| SCHEMBL7660747 | 0.77 | RXRA (0.45) | RXRAMEN1TP53CYP3A4ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700836-A | TOPICALLY ADMINISTERING TO TREAT PHOTODAMAGED SKIN | HOFFMANN-LA ROCHE INC. (US) | 1997-12-23 | — | — | US | disclosed |