Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.33 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
| ▸ | PPARG | P37231 | 6/20 | 0.32 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905737 | 0.90 | PDE4B (0.40) | PDE4APDE4BPDE4CPDE4DPPARG | |
| SCHEMBL8906651 | 0.88 | GPR119 (0.38) | PDE4APDE4BPDE4CPDE4DPPARG | |
| SCHEMBL8905548 | 0.84 | GPR119 (0.37) | — | |
| SCHEMBL8905804 | 0.83 | KDM4E (0.40) | PDE4APDE4DPPARG | |
| SCHEMBL8907335 | 0.83 | PPARG (0.39) | PDE4APDE4DPPARG | |
| SCHEMBL8906629 | 0.82 | GPR119 (0.39) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8905647 | 0.82 | CYP1A2 (0.33) | PPARGHCAR1 | |
| SCHEMBL8907533 | 0.81 | CYP3A4 (0.34) | PPARG | |
| SCHEMBL8905214 | 0.79 | PPARG (0.37) | PDE4APDE4DPPARG | |
| SCHEMBL8907613 | 0.79 | AGTR1 (0.37) | PDE4APDE4DPPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |