Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.39 |
| ▸ | PDE3B | Q13370 | 10/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 10/20 | 0.39 |
| ▸ | PDE2A | O00408 | 2/20 | 0.39 |
| ▸ | PDE1A | P54750 | 1/20 | 0.39 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.39 |
| ▸ | PDE1C | Q14123 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.34 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.34 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.34 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906651 | 0.95 | GPR119 (0.38) | GPR119PDE3BPDE3APDE2APDE1A | |
| SCHEMBL8905548 | 0.94 | GPR119 (0.37) | GPR119PDE3BPDE3APDE2APDE1A | |
| SCHEMBL8905734 | 0.83 | GPR119 (0.42) | GPR119PDE3BPDE3APDE2APDE1A | |
| SCHEMBL8906188 | 0.82 | PDE4A (0.33) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8906411 | 0.82 | GPR119 (0.38) | GPR119MEN1KMT2APDE4APDE4B | |
| SCHEMBL8905618 | 0.82 | KDM4E (0.38) | PDE3ASMN1; SMN2MEN1KMT2AMAPT | |
| SCHEMBL8905737 | 0.80 | PDE4B (0.40) | PDE3BPDE3APDE4APDE4BPDE4C | |
| SCHEMBL8789934 | 0.78 | AGTR1 (0.43) | — | |
| SCHEMBL8906593 | 0.78 | GPR119 (0.41) | GPR119PDE3BPDE3APDE2APDE1A | |
| SCHEMBL8905804 | 0.77 | KDM4E (0.40) | PDE3ASMN1; SMN2MEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |