Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.53 |
| ▸ | TSHR | P16473 | 2/20 | 0.53 |
| ▸ | GLA | P06280 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | ROCK2 | O75116 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | AGTR1 | P30556 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.45 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL966694 | 0.90 | MEN1 (0.69) | MEN1KMT2AALDH1A1TSHRGLA | |
| SCHEMBL27654625 | 0.82 | ALDH1A1 (0.60) | MEN1KMT2AALDH1A1TSHRGLA | |
| SCHEMBL11262493 | 0.81 | ALDH1A1 (0.58) | MEN1KMT2AALDH1A1TSHRGLA | |
| Hydrochloric Acid SCHEMBL3998159 | 0.79 | ALDH1A1 (0.51) | MEN1KMT2AALDH1A1TSHRGLA | |
| SCHEMBL8905438 | 0.77 | ROCK2 (0.60) | ALDH1A1MAPTROCK2KDM4EHDAC6 | |
| SCHEMBL9260027 | 0.77 | PTGES (0.48) | MEN1KMT2AALDH1A1ROCK2 | |
| SCHEMBL8791607 | 0.77 | ALDH1A1 (0.53) | MEN1KMT2AALDH1A1TSHRGLA | |
| SCHEMBL11546145 | 0.76 | MAPT (0.41) | ALDH1A1MAPTHPGDROCK2KDM4E | |
| SCHEMBL9340745 | 0.76 | TP53 (0.54) | MEN1KMT2AALDH1A1TSHRGLA | |
| SCHEMBL11176470 | 0.75 | ALDH1A1 (0.66) | MEN1KMT2AALDH1A1TSHRGLA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |