Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 6/20 | 0.59 |
| ▸ | DRD3 | P35462 | 6/20 | 0.59 |
| ▸ | DRD4 | P21917 | 5/20 | 0.59 |
| ▸ | HTR1A | P08908 | 1/20 | 0.44 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8907983 | 0.85 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL8906697 | 0.80 | DRD2 (0.72) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9024037 | 0.80 | DRD2 (0.55) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL8907838 | 0.78 | DRD2 (0.66) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL9528467 | 0.77 | RAB9A (0.42) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8907640 | 0.77 | DRD2 (0.67) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL8906622 | 0.75 | DRD2 (1.00) | DRD2DRD3DRD4 | |
| SCHEMBL8906350 | 0.73 | RAB9A (0.40) | NPC1RAB9ASMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL8906947 | 0.73 | DRD2 (0.70) | DRD2DRD3DRD4HTR1A | |
| SCHEMBL8906889 | 0.73 | DRD2 (0.72) | DRD2DRD3DRD4HTR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556332-B1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-03-20 | — | — | EP | claimed |
| WO-1992007831-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | claimed |
| US-5620988-A | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1997-04-15 | — | — | US | disclosed |
| EP-0556332-B1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5466698-A | Substituted tetrahydrophyridines and hydroxypiperidines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
| US-5273977-A | 1-Phenylethylidynealkylene-4-phenyl-1,2,5,6-tetrahydropyridines | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1992007831-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |