Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 11/20 | 0.40 |
| ▸ | NPC1 | O15118 | 8/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.40 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | MAPT | P10636 | 6/20 | 0.38 |
| ▸ | POLB | P06746 | 4/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | PTBP1 | P26599 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8906708 | 0.81 | DRD2 (0.32) | — | |
| SCHEMBL8906340 | 0.73 | DRD2 (0.59) | RAB9ANPC1SMN1; SMN2LMNAKDM4E | |
| SCHEMBL9202147 | 0.73 | DRD2 (0.51) | RAB9ANPC1ALDH1A1KMT2AHSD17B10 | |
| SCHEMBL8908199 | 0.70 | DRD2 (0.42) | — | |
| SCHEMBL8906800 | 0.68 | DRD2 (0.46) | — | |
| SCHEMBL9528467 | 0.66 | RAB9A (0.42) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL1483884 | 0.65 | RAB9A (0.61) | RAB9ANPC1SMN1; SMN2LMNAMAPT | |
| SCHEMBL9199464 | 0.64 | RAB9A (0.46) | RAB9ANPC1ALDH1A1KMT2AGAA | |
| SCHEMBL8908180 | 0.61 | GRIN1 (0.36) | — | |
| Hydrochloric Acid SCHEMBL9741845 | 0.59 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0556332-B1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-03-20 | — | — | EP | claimed |
| WO-1992007831-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | claimed |
| US-5620988-A | Substituted tetrahydropyridines and hydroxypiperidines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1997-04-15 | — | — | US | disclosed |
| EP-0556332-B1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER LAMBERT CO (US) | 1996-03-20 | — | — | EP | disclosed |
| US-5466698-A | Substituted tetrahydrophyridines and hydroxypiperidines as central nervous system agents | WARNER-LAMBERT COMPANY (US) | 1995-11-14 | — | — | US | disclosed |
| US-5273977-A | 1-Phenylethylidynealkylene-4-phenyl-1,2,5,6-tetrahydropyridines | WARNER-LAMBERT COMPANY (US) | 1993-12-28 | — | — | US | disclosed |
| WO-1992007831-A1 | SUBSTITUTED TETRAHYDROPYRIDINES AND HYDROXYPIPERIDINES AS CENTRAL NERVOUS SYSTEM AGENTS | WARNER-LAMBERT COMPANY (US) | 1992-05-14 | — | — | WO | disclosed |