Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 4/20 | 0.48 |
| ▸ | CYP26A1 | O43174 | 2/20 | 0.48 |
| ▸ | CYP26B1 | Q9NR63 | 1/20 | 0.48 |
| ▸ | RARA | P10276 | 8/20 | 0.43 |
| ▸ | RARB | P10826 | 8/20 | 0.43 |
| ▸ | RARG | P13631 | 8/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | CA12 | O43570 | 1/20 | 0.37 |
| ▸ | CA1 | P00915 | 1/20 | 0.37 |
| ▸ | CA2 | P00918 | 1/20 | 0.37 |
| ▸ | CA7 | P43166 | 1/20 | 0.37 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.37 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.37 |
| ▸ | CA9 | Q16790 | 1/20 | 0.37 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.37 |
| ▸ | RXRA | P19793 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | NPC1 | O15118 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908927 | 0.91 | CYP3A4 (0.55) | CYP3A4CYP26A1CYP26B1RARARARB | |
| SCHEMBL5084222 | 0.87 | CYP3A4 (0.63) | CYP3A4CYP26A1CYP26B1RARARARB | |
| SCHEMBL8907346 | 0.84 | RARA (0.44) | CYP3A4CYP26A1CYP26B1RARARARB | |
| SCHEMBL9256097 | 0.81 | CYP3A4 (0.57) | CYP3A4CYP26A1CYP26B1RARARARB | |
| SCHEMBL9189772 | 0.78 | CYP3A4 (0.42) | CYP3A4CYP26A1CYP26B1RARARARB | |
| SCHEMBL7713085 | 0.78 | RARA (0.45) | CYP3A4CYP26A1CYP26B1RARARARB | |
| SCHEMBL5084224 | 0.77 | CYP26A1 (0.72) | CYP3A4CYP26A1CYP26B1RARARARB | |
| SCHEMBL8907565 | 0.76 | CYP3A4 (0.64) | CYP3A4CYP26A1CYP26B1RARARARB | |
| SCHEMBL8908988 | 0.76 | CYP3A4 (0.64) | CYP3A4CYP26A1CYP26B1RARARARB | |
| SCHEMBL8907823 | 0.76 | CYP3A4 (0.60) | CYP3A4CYP26A1CYP26B1RARARARB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0514264-B1 | Biaromatic compounds derived from compounds having a salicylic configuration, their preparation process and their use in human and veterinary medicine and in cosmetics | CIRD GALDERMA (FR) | 1995-11-15 | — | — | EP | claimed |
| US-5654331-A | SKIN AND RESPIRATORY SYSTEM DISORDERS; ANTIINFLAMMATORY AGENTS; ANTIALLERGENS | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES GALDERMA (CIRD GALDERMA) (FR) | 1997-08-05 | — | — | US | disclosed |
| US-5476860-A | Diaromatic compounds derived from a salicylic unit and their use in human and veterinary medicine and in cosmetics | CENTRE INTERNATIONAL DE RECHERCHES DERMATOLOGIQUES (CIRD GALDERMA) (FR) | 1995-12-19 | — | — | US | disclosed |