Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.60 |
| ▸ | MMP8 | P22894 | 2/20 | 0.55 |
| ▸ | MMP12 | P39900 | 2/20 | 0.55 |
| ▸ | MMP13 | P45452 | 2/20 | 0.55 |
| ▸ | MMP1 | P03956 | 1/20 | 0.55 |
| ▸ | MMP7 | P09237 | 1/20 | 0.55 |
| ▸ | IDO1 | P14902 | 1/20 | 0.53 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | PTGES2 | Q9H7Z7 | 1/20 | 0.46 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.44 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15754219 | 0.87 | L3MBTL1 (0.64) | MEN1KMT2AMMP8MMP12MMP13 | |
| SCHEMBL3836194 | 0.85 | MMP8 (0.58) | MEN1KMT2AMMP8MMP12MMP13 | |
| SCHEMBL634317 | 0.83 | ALDH1A1 (0.66) | MEN1KMT2AMMP8MMP13MMP1 | |
| SCHEMBL3532040 | 0.83 | CA2 (0.56) | MEN1KMT2AMMP8MMP12MMP13 | |
| SCHEMBL6626226 | 0.83 | MEN1 (0.61) | MEN1KMT2AL3MBTL1POLBALDH1A1 | |
| SCHEMBL9002519 | 0.82 | MMP8 (0.59) | MEN1KMT2AMMP8MMP12MMP13 | |
| SCHEMBL8586492 | 0.80 | F10 (0.41) | MEN1KMT2AMMP8MMP12MMP13 | |
| SCHEMBL8587418 | 0.80 | GRIA4 (0.60) | MEN1KMT2AMMP8MMP12MMP13 | |
| SCHEMBL14719879 | 0.79 | MEN1 (0.77) | MEN1KMT2AL3MBTL1POLBALDH1A1 | |
| SCHEMBL3207695 | 0.79 | MMP8 (0.60) | MEN1KMT2AMMP8MMP12MMP13 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |
| US-5587393-A | ANGIOTENSIN ANTAGONIST USEFUL IN TREATING HYPERTENSION | DR. KARL THOMAE GMBH (DE) | 1996-12-24 | — | — | US | disclosed |
| US-5385925-A | Benzimidazoles, pharmaceutical compositions containing these compounds and processes for preparing them | DR. KARL THOMAE GMBH (DE) | 1995-01-31 | — | — | US | disclosed |