Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.45 |
| ▸ | EDNRA | P25101 | 1/20 | 0.41 |
| ▸ | DHODH | Q02127 | 1/20 | 0.41 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.40 |
| ▸ | PPARG | P37231 | 1/20 | 0.40 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | PIN1 | Q13526 | 2/20 | 0.39 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.39 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8905537 | 0.89 | DHODH (0.43) | KDM4ETDP1DHODHAGTR1PPARG | |
| SCHEMBL8905885 | 0.88 | TP53 (0.47) | AGTR1PPARGAGTR2 | |
| SCHEMBL8907873 | 0.86 | AGTR1 (0.46) | KDM4ETDP1AGTR1PPARGAGTR2 | |
| SCHEMBL8906713 | 0.83 | AGTR1 (0.45) | KDM4EAGTR1PPARGAGTR2 | |
| SCHEMBL8905585 | 0.82 | PPARG (0.43) | KDM4EEDNRAAGTR1PPARGAGTR2 | |
| SCHEMBL8906709 | 0.81 | PPARG (0.42) | KDM4EEDNRADHODHAGTR1PPARG | |
| SCHEMBL8906832 | 0.80 | AGTR1 (0.43) | AGTR1PPARGAGTR2 | |
| SCHEMBL8905963 | 0.80 | AGTR1 (0.41) | AGTR1PPARGAGTR2 | |
| SCHEMBL8905974 | 0.79 | PPARG (0.45) | KDM4EDHODHAGTR1PPARGAGTR2 | |
| SCHEMBL8788720 | 0.79 | AGTR1 (0.65) | AGTR1PPARGAGTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5684029-A | HYPOTENSIVE AGENTS | KARL THOMAE GMBH (DE) | 1997-11-04 | — | — | US | disclosed |