Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.55 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.55 |
| ▸ | TSHR | P16473 | 2/20 | 0.55 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.55 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | DRD4 | P21917 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.47 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | DRD2 | P14416 | 1/20 | 0.47 |
| ▸ | DRD3 | P35462 | 1/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908153 | 0.87 | KDM4E (0.57) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL8508337 | 0.85 | CYP2D6 (0.58) | LMNASIGMAR1CCNT1CDK9DRD2 | |
| SCHEMBL9092391 | 0.79 | SIGMAR1 (0.49) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7864576 | 0.79 | LMNA (0.55) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7854831 | 0.77 | LMNA (0.58) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7854934 | 0.77 | LMNA (0.67) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7861680 | 0.75 | TSHR (0.73) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7862516 | 0.75 | MAPT (0.62) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL9726233 | 0.75 | SIGMAR1 (0.61) | SIGMAR1HTR1A | |
| SCHEMBL7865141 | 0.74 | LMNA (0.66) | KDM4ELMNAALDH1A1ALOX15TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698565-A | TREATMENT OF PSYCHOTIC DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-12-16 | — | — | US | disclosed |