Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.57 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.57 |
| ▸ | TSHR | P16473 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.57 |
| ▸ | MAPT | P10636 | 2/20 | 0.54 |
| ▸ | GAA | P10253 | 2/20 | 0.54 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.46 |
| ▸ | DRD4 | P21917 | 1/20 | 0.46 |
| ▸ | DRD3 | P35462 | 1/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | THPO | P40225 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908157 | 0.87 | KDM4E (0.55) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL9092391 | 0.78 | SIGMAR1 (0.49) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL1061316 | 0.76 | SIGMAR1 (0.55) | GAASIGMAR1HTR1AHTTDRD2 | |
| SCHEMBL7854831 | 0.76 | LMNA (0.58) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7854934 | 0.76 | LMNA (0.67) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7862476 | 0.75 | ABCB1 (0.65) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7864576 | 0.75 | LMNA (0.55) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7861680 | 0.74 | TSHR (0.73) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL7862516 | 0.74 | MAPT (0.62) | KDM4ELMNAALDH1A1ALOX15TSHR | |
| SCHEMBL10852629 | 0.73 | ALDH1A1 (0.50) | ALDH1A1ALOX15TSHRGAASIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5698565-A | TREATMENT OF PSYCHOTIC DISORDERS | HOFFMANN-LA ROCHE INC. (US) | 1997-12-16 | — | — | US | disclosed |