Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.40 |
| ▸ | HSD11B1 | P28845 | 6/20 | 0.38 |
| ▸ | OPRM1 | P35372 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | CCR5 | P51681 | 1/20 | 0.31 |
| ▸ | DRD2 | P14416 | 1/20 | 0.30 |
| ▸ | DRD3 | P35462 | 1/20 | 0.30 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.30 |
| ▸ | RORC | P51449 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8908767 | 0.81 | SIGMAR1 (0.46) | SIGMAR1HSD11B1 | |
| SCHEMBL8908820 | 0.81 | SIGMAR1 (0.64) | SIGMAR1DRD2DRD3KCNH2 | |
| SCHEMBL8099281 | 0.81 | SIGMAR1 (0.64) | SIGMAR1DRD2DRD3KCNH2 | |
| SCHEMBL8908876 | 0.81 | SIGMAR1 (0.64) | SIGMAR1DRD2DRD3KCNH2 | |
| SCHEMBL8908596 | 0.81 | SIGMAR1 (0.64) | SIGMAR1DRD2DRD3KCNH2 | |
| SCHEMBL8090385 | 0.81 | SIGMAR1 (0.64) | SIGMAR1DRD2DRD3KCNH2 | |
| SCHEMBL8910605 | 0.80 | SIGMAR1 (0.60) | SIGMAR1HSD11B1 | |
| SCHEMBL8909799 | 0.75 | SIGMAR1 (0.43) | SIGMAR1OPRM1OPRL1 | |
| SCHEMBL8090139 | 0.72 | HSD11B1 (0.47) | HSD11B1ALDH1A1NPC1LMNA | |
| SCHEMBL8909813 | 0.71 | SIGMAR1 (0.45) | SIGMAR1HSD11B1ALDH1A1NPC1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658923-A | USED IN TREATING DISEASES RELATED TO SIGMA-RECEPTOR, SUCH AS SCHIZOPHRENIA | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-08-19 | — | — | US | disclosed |