Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 11/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
| ▸ | EPHX1 | P07099 | 3/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.31 |
| ▸ | PEPD | P12955 | 1/20 | 0.31 |
| ▸ | XPNPEP1 | Q9NQW7 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909879 | 0.76 | SIGMAR1 (0.43) | SIGMAR1HIF1A | |
| SCHEMBL8910607 | 0.75 | BPTF (0.49) | SIGMAR1HIF1AEPHX1ALDH1A1 | |
| SCHEMBL8910246 | 0.73 | SIGMAR1 (0.43) | SIGMAR1HIF1AEPHX1 | |
| SCHEMBL5499445 | 0.73 | SIGMAR1 (0.47) | SIGMAR1HIF1A | |
| SCHEMBL8909808 | 0.72 | SIGMAR1 (0.53) | SIGMAR1HIF1A | |
| SCHEMBL8910605 | 0.69 | SIGMAR1 (0.60) | SIGMAR1HIF1A | |
| SCHEMBL8908767 | 0.68 | SIGMAR1 (0.46) | SIGMAR1HIF1A | |
| SCHEMBL8909815 | 0.68 | SIGMAR1 (0.40) | SIGMAR1HIF1AEPHX1 | |
| SCHEMBL8909813 | 0.65 | SIGMAR1 (0.45) | SIGMAR1HIF1ANPC1ALDH1A1 | |
| SCHEMBL8103079 | 0.65 | SIGMAR1 (0.61) | SIGMAR1HIF1AEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5658923-A | USED IN TREATING DISEASES RELATED TO SIGMA-RECEPTOR, SUCH AS SCHIZOPHRENIA | ASAHI KASEI KOGYO KABUSHIKI KAISHA (JP) | 1997-08-19 | — | — | US | disclosed |