Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | F2R | P25116 | 1/20 | 0.37 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.36 |
| ▸ | REN | P00797 | 3/20 | 0.35 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.35 |
| ▸ | SIRT2 | Q8IXJ6 | 6/20 | 0.35 |
| ▸ | CCKBR | P32239 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910552 | 0.93 | REN (0.36) | F2RP2RX1RENSIRT2 | |
| SCHEMBL8909424 | 0.93 | SIRT2 (0.34) | P2RX1RENAKR1C3SIRT2 | |
| SCHEMBL8910197 | 0.93 | REN (0.36) | F2RP2RX1RENSIRT2 | |
| SCHEMBL8910523 | 0.91 | KDM4E (0.38) | AKR1C3SIRT2 | |
| SCHEMBL8909363 | 0.83 | P2RX1 (0.52) | F2RP2RX1RENAKR1C3MDM2 | |
| SCHEMBL8910700 | 0.83 | REN (0.40) | F2RP2RX1RENAKR1C3CCKBR | |
| SCHEMBL8909618 | 0.77 | SIRT2 (0.37) | RENSIRT2 | |
| SCHEMBL9800700 | 0.75 | REN (0.51) | F2RP2RX1RENSIRT2 | |
| SCHEMBL8909154 | 0.74 | REN (0.41) | F2RP2RX1REN | |
| SCHEMBL9800634 | 0.74 | P2RX1 (0.49) | F2RP2RX1REN |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |