SCHEMBL8910552

NC(=O)C(Cc1cn(C(c2ccccc2)(c2ccccc2)c2ccccc2)cn1)N(C(=O)c1cc2cc(O)ccc2[nH]1)[C@@H](CC1CCCCC1)[C@@H](O)[C@@H](O)C1CC1

nearest known ligand 0.36

Predicted protein targets (top 15)

	gene	UniProt	supporting neighbours	confidence
▸	REN	P00797	2/20	0.36

▸	SIRT2	Q8IXJ6	12/20	0.35

▸	GRIN2D	O15399	1/20	0.34

▸	GRIN3B	O60391	1/20	0.34

▸	GRIN1	Q05586	1/20	0.34

▸	GRIN2A	Q12879	1/20	0.34

▸	GRIN2B	Q13224	1/20	0.34

▸	GRIN2C	Q14957	1/20	0.34

▸	GRIN3A	Q8TCU5	1/20	0.34

▸	P2RX1	P51575	1/20	0.33

▸	MC4R	P32245	1/20	0.32

▸	MC5R	P33032	1/20	0.32

▸	MC3R	P41968	1/20	0.32

▸	F2R	P25116	1/20	0.32

▸	NMBR	P28336	1/20	0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL8908848	0.93	F2R (0.37)	RENSIRT2P2RX1F2R
SCHEMBL8909424	0.93	SIRT2 (0.34)	RENSIRT2P2RX1
SCHEMBL8910197	0.93	REN (0.36)	RENSIRT2P2RX1F2R
SCHEMBL8910523	0.91	KDM4E (0.38)	SIRT2
SCHEMBL8909154	0.82	REN (0.41)	RENGRIN2DGRIN3BGRIN1GRIN2A
SCHEMBL9800700	0.82	REN (0.51)	RENSIRT2P2RX1F2R
SCHEMBL8909363	0.76	P2RX1 (0.52)	RENP2RX1F2R
SCHEMBL8910700	0.76	REN (0.40)	RENP2RX1F2R
SCHEMBL8909618	0.75	SIRT2 (0.37)	RENSIRT2
SCHEMBL9800715	0.75	REN (0.52)	RENP2RX1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-5688946-A	DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS	HOFFMANN LA ROCHE INC. (US)	1997-11-18	—	—	US	disclosed