Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 5/20 | 0.41 |
| ▸ | PYGL | P06737 | 1/20 | 0.34 |
| ▸ | P2RX1 | P51575 | 1/20 | 0.34 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.32 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.32 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.32 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.32 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.32 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.32 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.32 |
| ▸ | MC4R | P32245 | 1/20 | 0.32 |
| ▸ | MC5R | P33032 | 1/20 | 0.32 |
| ▸ | MC3R | P41968 | 1/20 | 0.32 |
| ▸ | ABL1 | P00519 | 1/20 | 0.31 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.31 |
| ▸ | KIT | P10721 | 1/20 | 0.31 |
| ▸ | BCR | P11274 | 1/20 | 0.31 |
| ▸ | FLT3 | P36888 | 1/20 | 0.31 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
| ▸ | SMAD3 | P84022 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8910563 | 0.92 | REN (0.41) | RENPYGLP2RX1FLT3 | |
| SCHEMBL8909458 | 0.92 | PYGL (0.36) | RENPYGLP2RX1 | |
| SCHEMBL8910700 | 0.91 | REN (0.40) | RENPYGLP2RX1F2R | |
| SCHEMBL8910252 | 0.90 | KDM4E (0.39) | RENPYGLPDGFRBFLT3IDO1 | |
| SCHEMBL8910552 | 0.82 | REN (0.36) | RENP2RX1GRIN2DGRIN3BGRIN1 | |
| SCHEMBL9800690 | 0.79 | REN (0.59) | RENPYGLP2RX1F2R | |
| SCHEMBL8909363 | 0.79 | P2RX1 (0.52) | RENP2RX1F2R | |
| SCHEMBL8910197 | 0.75 | REN (0.36) | RENPYGLP2RX1F2R | |
| SCHEMBL8909424 | 0.75 | SIRT2 (0.34) | RENPYGLP2RX1 | |
| SCHEMBL8908848 | 0.74 | F2R (0.37) | RENP2RX1F2R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5688946-A | DIPEPTIDES FOR HYPOTENSIVE AGENTS AND CARDIOVASCULAR DISORDERS | HOFFMANN LA ROCHE INC. (US) | 1997-11-18 | — | — | US | disclosed |