Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | TSHR | P16473 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | THRA | P10827 | 1/20 | 0.50 |
| ▸ | VDR | P11473 | 1/20 | 0.50 |
| ▸ | NAMPT | P43490 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | CCR2 | P41597 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NPC1L1 | Q9UHC9 | 1/20 | 0.44 |
| ▸ | FNTA | P49354 | 1/20 | 0.44 |
| ▸ | FNTB | P49356 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4071830 | 0.89 | SIGMAR1 (0.49) | SIGMAR1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL8131286 | 0.82 | SIGMAR1 (0.58) | SIGMAR1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL8870127 | 0.80 | SIGMAR1 (0.50) | SIGMAR1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL8870137 | 0.80 | SIGMAR1 (0.50) | SIGMAR1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL20564153 | 0.79 | KMT2A (0.72) | SIGMAR1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL15841183 | 0.79 | ALDH1A1 (0.67) | SIGMAR1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL22859865 | 0.79 | MEN1 (0.67) | SIGMAR1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL3843148 | 0.79 | NAMPT (0.66) | MEN1KMT2ANAMPTKDM4EPKM | |
| SCHEMBL23113054 | 0.79 | SIGMAR1 (0.52) | SIGMAR1ALDH1A1MEN1TSHRKMT2A | |
| SCHEMBL14619656 | 0.79 | DRD2 (0.60) | SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1997014689-A1 | ARYL-PIPERAZINE CYCLIC AMINE DERIVATIVES, PREPARATION THEREOF AND PHARMACEUTICAL COMPOSITIONS CONTAINING SAME | PIERRE FABRE MEDICAMENT (FR) | 1997-04-24 | — | — | WO | disclosed |