Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 5/20 | 0.40 |
| ▸ | FEN1 | P39748 | 5/20 | 0.40 |
| ▸ | KIF11 | P52732 | 3/20 | 0.38 |
| ▸ | CFTR | P13569 | 1/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.37 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.37 |
| ▸ | CA12 | O43570 | 1/20 | 0.36 |
| ▸ | CA1 | P00915 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | CA6 | P23280 | 1/20 | 0.36 |
| ▸ | CA5A | P35218 | 1/20 | 0.36 |
| ▸ | CA7 | P43166 | 1/20 | 0.36 |
| ▸ | CA9 | Q16790 | 1/20 | 0.36 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.36 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.35 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8551071 | 0.85 | NTRK1 (0.41) | CFTRNR1H2NR1H3CA12CA1 | |
| SCHEMBL8554062 | 0.70 | CA1 (0.44) | CA12CA1CA2CA4CA7 | |
| SCHEMBL8908994 | 0.68 | MAOB (0.47) | CA12CA1CA2CA4CA7 | |
| SCHEMBL6026444 | 0.65 | BRD4 (0.43) | ALOX5APFEN1CA12CA1CA2 | |
| SCHEMBL6728769 | 0.65 | FEN1 (0.46) | ALOX5APFEN1CA1CA2PTGS2 | |
| SCHEMBL8659162 | 0.65 | KIF11 (0.55) | ALOX5APFEN1KIF11PTGS2PTGS1 | |
| SCHEMBL8663462 | 0.65 | ALOX5AP (0.46) | ALOX5APFEN1KIF11PTGS2PTGS1 | |
| SCHEMBL6986037 | 0.63 | EDNRB (0.56) | ALOX5APFEN1 | |
| SCHEMBL6724115 | 0.63 | KIF11 (0.78) | KIF11PTGS2PTGS1 | |
| SCHEMBL18230068 | 0.63 | PIK3CD (0.40) | ALOX5APFEN1NR1H2NR1H3PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | disclosed |