Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 2/20 | 0.47 |
| ▸ | EDNRB | P24530 | 5/20 | 0.40 |
| ▸ | EDNRA | P25101 | 5/20 | 0.40 |
| ▸ | CA1 | P00915 | 4/20 | 0.40 |
| ▸ | CA2 | P00918 | 4/20 | 0.40 |
| ▸ | CA12 | O43570 | 3/20 | 0.40 |
| ▸ | CA9 | Q16790 | 3/20 | 0.40 |
| ▸ | HPGDS | O60760 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.39 |
| ▸ | CA4 | P22748 | 1/20 | 0.38 |
| ▸ | CA7 | P43166 | 1/20 | 0.38 |
| ▸ | BRD4 | O60885 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.38 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.38 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.38 |
| ▸ | LTA4H | P09960 | 1/20 | 0.36 |
| ▸ | PDIA6 | Q15084 | 1/20 | 0.35 |
| ▸ | ACLY | P53396 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554062 | 0.88 | CA1 (0.44) | MAOBEDNRBEDNRACA1CA2 | |
| SCHEMBL8551071 | 0.82 | NTRK1 (0.41) | MAOBEDNRBEDNRACA1CA2 | |
| SCHEMBL8547875 | 0.78 | CA2 (0.45) | MAOBCA1CA2CA12CA9 | |
| SCHEMBL7408121 | 0.78 | HPGDS (0.44) | MAOBEDNRBEDNRACA1CA2 | |
| SCHEMBL6026444 | 0.75 | BRD4 (0.43) | EDNRBEDNRACA1CA2CA12 | |
| SCHEMBL6986037 | 0.73 | EDNRB (0.56) | EDNRBEDNRAHPGDSLTA4H | |
| SCHEMBL942521 | 0.73 | HPGDS (0.47) | MAOBEDNRBEDNRAHPGDSHPGD | |
| SCHEMBL7408116 | 0.73 | BRD4 (0.41) | EDNRBEDNRACA1CA2CA12 | |
| SCHEMBL5174048 | 0.72 | EDNRB (0.41) | EDNRBEDNRAHPGDSHPGDBRD4 | |
| SCHEMBL19815373 | 0.70 | HPGDS (0.45) | HPGDSHPGDBRD4IMPDH2LTA4H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | disclosed |