Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 5/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.41 |
| ▸ | HDAC6 | Q9UBN7 | 3/20 | 0.41 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.41 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | MIF | P14174 | 1/20 | 0.39 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.39 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4405120 | 0.87 | HDAC6 (0.45) | HDAC6HDAC4HDAC1MAPTHSD11B1 | |
| SCHEMBL8560735 | 0.82 | PTGS2 (0.43) | PTGS2PTGS1PIK3CDSLC40A1MAPT | |
| SCHEMBL8560251 | 0.81 | HDAC6 (0.48) | HDAC6HDAC4HDAC1MAPTLMNA | |
| SCHEMBL8154450 | 0.80 | KMO (0.47) | HDAC6HDAC4HDAC1MAPTHSD11B1 | |
| Sulfamide SCHEMBL4639002 | 0.78 | PTGS2 (0.46) | PTGS2PTGS1MAPTMIFSMN1; SMN2 | |
| SCHEMBL9026371 | 0.78 | KMT2A (0.41) | PTGS2PTGS1PIK3CDSLC40A1MAPT | |
| SCHEMBL8140595 | 0.77 | MIF (0.43) | PTGS2PTGS1MAPTMIFABCB1 | |
| SCHEMBL8631663 | 0.76 | MAPK14 (0.46) | PTGS2PTGS1ERAP1PPARAHTR6 | |
| SCHEMBL8629545 | 0.75 | NPC1 (0.41) | PTGS2PTGS1ERAP1PPARALMNA | |
| SCHEMBL8153075 | 0.75 | PTGS2 (0.55) | PTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | claimed |
| US-5700816-A | ANTIARTHRITIC AGENTS | G.D. SEARLE & CO. | 1997-12-23 | — | — | US | disclosed |