Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | PPARA | Q07869 | 1/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 5/20 | 0.40 |
| ▸ | PTGS1 | P23219 | 4/20 | 0.40 |
| ▸ | ACLY | P53396 | 2/20 | 0.40 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.40 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | AAK1 | Q2M2I8 | 1/20 | 0.39 |
| ▸ | HTR6 | P50406 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8634385 | 0.90 | ACLY (0.42) | HTTPTGS2PTGS1ACLYKDM4E | |
| SCHEMBL8631745 | 0.88 | PTGS2 (0.41) | PPARAPTGS2PTGS1ERAP1SCN9A | |
| SCHEMBL8631851 | 0.87 | MAPT (0.39) | HTTPTGS2ALDH1A1 | |
| SCHEMBL8630562 | 0.86 | CCR4 (0.42) | PPARAPTGS2PTGS1 | |
| SCHEMBL8635104 | 0.86 | PPARA (0.39) | NPC1HTTPPARAPTGS2PTGS1 | |
| SCHEMBL8630945 | 0.86 | PPARA (0.39) | NPC1HTTPPARAPTGS2PTGS1 | |
| SCHEMBL8629307 | 0.85 | GAA (0.47) | ALDH1A1LMNASMN1; SMN2CYP2C9 | |
| SCHEMBL8631722 | 0.85 | PPARA (0.41) | PPARAPTGS2PTGS1ACLYSCN9A | |
| SCHEMBL8629013 | 0.85 | PPARA (0.39) | NPC1HTTPPARAPTGS2PTGS1 | |
| SCHEMBL8631761 | 0.85 | PTGS2 (0.44) | NPC1HTTPPARAPTGS2PTGS1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756530-A | NON-STEROIDAL ANTIINFLAMMATORY AGENTS WITH REDUCED SIDE EFFECTS | G. D. SEARLE & CO. (US) | 1998-05-26 | — | — | US | disclosed |