Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.37 |
| ▸ | GRM6 | O15303 | 1/20 | 0.36 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.36 |
| ▸ | CDC7 | O00311 | 1/20 | 0.36 |
| ▸ | DBF4 | Q9UBU7 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.35 |
| ▸ | MAPT | P10636 | 5/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | RAB9A | P51151 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | ALPL | P05186 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 3/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CASP3 | P42574 | 1/20 | 0.34 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.34 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.34 |
| ▸ | TRPM8 | Q7Z2W7 | 2/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8909809 | 0.91 | TSHR (0.37) | TSHRGRM6PRKCZMAPK14MAPT | |
| SCHEMBL8910758 | 0.88 | DHODH (0.38) | TSHRMAPTALDH1A1NPC1RAB9A | |
| SCHEMBL8909629 | 0.81 | CA12 (0.39) | MAPTALDH1A1SMN1; SMN2HPGDGAA | |
| SCHEMBL9434374 | 0.80 | SMAD3 (0.39) | MAPTALDH1A1SMN1; SMN2GAANPSR1 | |
| SCHEMBL8909720 | 0.80 | DHODH (0.38) | MAPTALDH1A1NPC1RAB9AHPGD | |
| SCHEMBL8912086 | 0.80 | CYP2C9 (0.39) | TSHRMAPTALDH1A1RAB9AHPGD | |
| SCHEMBL8911562 | 0.80 | POLB (0.40) | GRM6PRKCZMAPTALDH1A1NPC1 | |
| SCHEMBL8910230 | 0.78 | GABRA1 (0.38) | TSHRMAPTALDH1A1SMN1; SMN2HPGD | |
| SCHEMBL1388445 | 0.78 | CA12 (0.37) | MAPTALDH1A1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL9434967 | 0.75 | MAPT (0.42) | TSHRMAPTALDH1A1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |