SCHEMBL8909515

SCHEMBL8909515

CCOCCN(CCOCC)c1nc(N/N=C/c2ccc(OC(F)(F)F)cc2)nc(Nc2ccc(F)c(C(F)(F)F)c2)n1

nearest known ligand 0.37

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MAPT P10636 6/20 0.37
MEN1 O00255 5/20 0.37
KMT2A Q03164 5/20 0.37
ALDH1A1 P00352 3/20 0.37
KDM4E B2RXH2 2/20 0.37
SMN1; SMN2 Q16637 1/20 0.37
CA12 O43570 3/20 0.35
CA1 P00915 3/20 0.35
CA2 P00918 3/20 0.35
CA9 Q16790 3/20 0.35
SCN9A Q15858 1/20 0.35
GAA P10253 3/20 0.35
NPC1 O15118 1/20 0.35
MITF O75030 1/20 0.35
RAB9A P51151 1/20 0.35
LMNA P02545 2/20 0.34
HPGD P15428 1/20 0.34
ALOX12 P18054 1/20 0.34
L3MBTL1 Q9Y468 1/20 0.34
CHRNA7 P36544 4/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8908463 0.82 CHRNA7 (0.48) MEN1KMT2ACA12CA1CA2
SCHEMBL605711 0.79 SCN9A (0.44) MEN1KMT2ACA12CA1CA2
SCHEMBL605710 0.79 SCN9A (0.44) MEN1KMT2ACA12CA1CA2
SCHEMBL8909084 0.79 SCN9A (0.44) MEN1KMT2ACA12CA1CA2
SCHEMBL417463 0.79 MEN1 (0.44) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL416612 0.79 MEN1 (0.44) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL10242562 0.79 MEN1 (0.44) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL8909735 0.79 DDX3X (0.43) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL8908800 0.78 CHRNA7 (0.50) MAPTMEN1KMT2AALDH1A1KDM4E
SCHEMBL8910212 0.77 MAPT (0.44) MAPTMEN1KMT2AALDH1A1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 US disclosed
US-8188273-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES, LLC. (US) 2012-05-29 US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 US disclosed
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2012-02-16 US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 US disclosed
US-8067588-B2 Insecticidal (1,3,5)-triazinyl phenyl hydrazones DOW AGROSCIENCES LLC (US) 2011-11-29 US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 US disclosed
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES DOW AGROSCIENCES LLC (US) 2009-04-09 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20090093481-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ MAPT 2948/4885MEN1 3633/4885KMT2A 1091/4885
US-20120040837-A1 INSECTICIDAL (1,3,5)-TRIAZINYL PHENYL HYDRAZONES HELZ, API5, CRYZ MAPT 2948/4885MEN1 3633/4885KMT2A 1091/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.