Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8142537 | 0.80 | MYC (0.34) | ALDH1A1 | |
| SCHEMBL8910392 | 0.80 | CCNB2 (0.32) | LMNA | |
| SCHEMBL8536552 | 0.76 | GAA (0.32) | ALDH1A1LMNA | |
| SCHEMBL9057850 | 0.75 | MYC (0.36) | — | |
| SCHEMBL8910714 | 0.74 | ALDH1A1 (0.34) | ALDH1A1LMNA | |
| SCHEMBL8909578 | 0.74 | HPGD (0.41) | ALDH1A1 | |
| SCHEMBL8149445 | 0.72 | TERT (0.36) | — | |
| SCHEMBL8537456 | 0.72 | — | — | |
| SCHEMBL8154329 | 0.72 | KMT2A (0.31) | ALDH1A1LMNA | |
| SCHEMBL8142555 | 0.71 | NPC1 (0.40) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5679694-A | LOW TOXICITY AGAINST NORMAL CELL LINES | THE WELLCOME FOUNDATION LTD. (GB) | 1997-10-21 | — | — | US | claimed |
| CN-1088209-A | Heterogeneous ring compound | WELLCOME FOUND (GB) | 1994-06-22 | — | — | CN | disclosed |
| WO-1994002483-A1 | TETRACYCLIC COMPOUNDS PROCESS AND INTERMEDIATES FOR THEIR PREPARATION AND THEIR USE AS ANTITUMOUR AGENTS | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-02-03 | — | — | WO | disclosed |