SCHEMBL8910486

SCHEMBL8910486

CN1CCc2c(O)ccc(Cl)c2CC1

nearest known ligand 0.62

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
ADRA2A P08913 3/20 0.55
ADRA2B P18089 3/20 0.55
ADRA2C P18825 3/20 0.55
ADRA1D P25100 2/20 0.55
ADRA1A P35348 2/20 0.55
ADRA1B P35368 2/20 0.55
CYP2D6 P10635 1/20 0.55
NPSR1 Q6W5P4 1/20 0.53
DRD2 P14416 4/20 0.50
DRD1 P21728 4/20 0.50
DRD5 P21918 4/20 0.50
DRD3 P35462 3/20 0.50
DRD4 P21917 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL10350068 0.81 PNMT (0.50) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL18034996 0.78 ADRA2A (0.58) ADRA2AADRA2BADRA2CADRA1DADRA1A
Chlorindanol SCHEMBL615288 0.77 CYP3A4 (0.42) NPSR1
Chlorindanol SCHEMBL29929703 0.77 CYP3A4 (0.42) NPSR1
SCHEMBL10773279 0.77 BCL2L1 (0.45)
SCHEMBL10349225 0.77 DRD2 (0.45) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL7792087 0.77 ADRA2A (0.55) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL8910139 0.77 ADRA2A (0.52) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL8911912 0.76 ADRA2A (0.53) ADRA2AADRA2BADRA2CADRA1DADRA1A
SCHEMBL8910895 0.73 ADRA2A (0.50) ADRA2AADRA2BADRA2CADRA1DADRA1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5639748-A HYPOTENSIVE AGENTS SMITHKLINE BEECHAM CORPORATION (US) 1997-06-17 US disclosed
EP-0630372-A1 HETEROALKOXY BENZAZEPINES SMITHKLINE BEECHAM CORPORATION (US) 1994-12-28 EP disclosed
EP-0603314-A4 CHEMICAL COMPOUNDS. SMITHKLINE BEECHAM CORP (US) 1994-08-24 EP disclosed
EP-0630372-A4 HETEROALKOXY BENZAZEPINES. SMITHKLINE BEECHAM CORP (US) 1994-07-05 EP disclosed
EP-0603314-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1994-06-29 EP disclosed
WO-1993004686-A1 CHEMICAL COMPOUNDS SMITHKLINE BEECHAM CORPORATION (US) 1993-03-18 WO disclosed
WO-1993003015-A1 HETEROALKOXY BENZAZEPINES SMITHKLINE BEECHAM CORPORATION (US) 1993-02-18 WO disclosed
EP-0238281-B1 SELECTIVE ALPHA-ADRENERGIC RECEPTOR ANTAGONISTS SMITHKLINE BEECHAM CORPORATION (US) 1990-05-16 EP disclosed
EP-0238281-A1 Selective alpha-adrenergic receptor antagonists SMITHKLINE BEECHAM CORPORATION (US) 1987-09-23 EP disclosed
US-4683229-A HYPOTENSIVE AGENTS SMITHKLINE BECKMAN CORPORATION (US) 1987-07-28 US disclosed
US-4469634-A Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines SMITHKLINE BECKMAN CORPORATION (US) 1984-09-04 US disclosed
EP-0103961-A1 Allyloxy- and allylthio-2,3,4,5-tetrahydro-1H-3-benzazepines SMITHKLINE BECKMAN CORPORATION (US) 1984-03-28 EP disclosed