Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP2 | O95551 | 3/20 | 0.42 |
| ▸ | PDPK1 | O15530 | 3/20 | 0.40 |
| ▸ | MET | P08581 | 1/20 | 0.39 |
| ▸ | KDM1A | O60341 | 3/20 | 0.39 |
| ▸ | MAOA | P21397 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | AURKA | O14965 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.36 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.36 |
| ▸ | HTR6 | P50406 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30341566 | 1.00 | TDP2 (0.42) | TDP2PDPK1METKDM1AMAOA | |
| SCHEMBL8915989 | 0.88 | MET (0.43) | TDP2PDPK1METKDM1AMAOA | |
| Hydrochloric Acid SCHEMBL8912504 | 0.87 | MET (0.42) | TDP2PDPK1METKDM1AMAOA | |
| SCHEMBL22770286 | 0.79 | MET (0.38) | TDP2METKDM1A | |
| SCHEMBL8914677 | 0.79 | SMN1; SMN2 (0.44) | TDP2KDM1AALDH1A1 | |
| SCHEMBL21856169 | 0.77 | F7 (0.44) | TDP2 | |
| SCHEMBL29506005 | 0.77 | F7 (0.44) | TDP2 | |
| SCHEMBL8914076 | 0.76 | KCNH2 (0.51) | — | |
| SCHEMBL28905294 | 0.75 | PARP10 (0.44) | TDP2KDRAURKB | |
| SCHEMBL28464048 | 0.75 | PARP1 (0.44) | TDP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |
| EP-0431943-A2 | Nitrogen-containing spirocycles | MERCK & CO. INC. (US) | 1991-06-12 | — | — | EP | disclosed |