Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SLC2A2 | P11168 | 2/20 | 0.38 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HTR1A | P08908 | 1/20 | 0.36 |
| ▸ | HTR7 | P34969 | 1/20 | 0.36 |
| ▸ | TDP2 | O95551 | 1/20 | 0.36 |
| ▸ | KDM1A | O60341 | 1/20 | 0.36 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.36 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22770286 | 0.91 | MET (0.38) | ADRA1DHTR1AHTR7TDP2KDM1A | |
| SCHEMBL8913831 | 0.90 | HTR2A (0.42) | SMN1; SMN2GAAALDH1A1HTR1AHTR7 | |
| SCHEMBL22789596 | 0.85 | GPR119 (0.46) | ALDH1A1 | |
| SCHEMBL29992332 | 0.85 | GPR119 (0.46) | ALDH1A1 | |
| SCHEMBL30341566 | 0.79 | TDP2 (0.42) | ALDH1A1TDP2KDM1A | |
| SCHEMBL8912487 | 0.79 | TDP2 (0.42) | ALDH1A1TDP2KDM1A | |
| SCHEMBL8913591 | 0.79 | GFER (0.41) | SMN1; SMN2GAAALDH1A1 | |
| SCHEMBL8914076 | 0.78 | KCNH2 (0.51) | ADRA1DADRA1AADRA1B | |
| SCHEMBL22789619 | 0.78 | GPR119 (0.46) | — | |
| SCHEMBL8916017 | 0.76 | HTR2A (0.52) | GAAADRA1DALDH1A1ADRA1AADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5633247-A | ANTIARRTHYMIA AGENT | MERCK & CO., INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5206240-A | Antiarrhythmia agents | MERCK & CO., INC. (US) | 1993-04-27 | — | — | US | disclosed |