Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 6/20 | 0.55 |
| ▸ | MMP2 | P08253 | 6/20 | 0.55 |
| ▸ | MMP3 | P08254 | 6/20 | 0.55 |
| ▸ | MMP7 | P09237 | 6/20 | 0.55 |
| ▸ | MMP9 | P14780 | 6/20 | 0.55 |
| ▸ | MMP13 | P45452 | 6/20 | 0.55 |
| ▸ | CAPN1 | P07384 | 1/20 | 0.52 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.45 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8916336 | 0.88 | GAA (0.48) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL8915074 | 0.88 | MMP2 (0.50) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL8912748 | 0.80 | MMP2 (0.63) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL14943559 | 0.78 | MMP2 (0.71) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL8913859 | 0.77 | CTSL (0.56) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL8915393 | 0.75 | ALDH1A1 (0.51) | MMP1MMP2MMP9MMP13ADAMTS4 | |
| SCHEMBL8914340 | 0.75 | CYP3A4 (0.47) | SLC1A3SLC1A2SLC1A1CYP3A4MMP12 | |
| SCHEMBL3842066 | 0.75 | MMP2 (0.91) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL2161562 | 0.75 | MMP2 (0.91) | MMP1MMP2MMP3MMP7MMP9 | |
| SCHEMBL6797666 | 0.75 | MMP2 (0.91) | MMP1MMP2MMP3MMP7MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |
| WO-1993005014-A1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO-WEDROPHARM GMBH (DE) | 1993-03-18 | — | — | WO | disclosed |