Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 3/20 | 0.56 |
| ▸ | CTSS | P25774 | 3/20 | 0.56 |
| ▸ | CTSK | P43235 | 3/20 | 0.56 |
| ▸ | TP53 | P04637 | 1/20 | 0.56 |
| ▸ | MMP2 | P08253 | 9/20 | 0.54 |
| ▸ | MMP9 | P14780 | 6/20 | 0.54 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.51 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.50 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.50 |
| ▸ | CTSB | P07858 | 2/20 | 0.48 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.48 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | MMP1 | P03956 | 1/20 | 0.47 |
| ▸ | MMP3 | P08254 | 1/20 | 0.47 |
| ▸ | MMP7 | P09237 | 1/20 | 0.47 |
| ▸ | MMP13 | P45452 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8915081 | 0.92 | MMP2 (0.56) | CTSLCTSSCTSKMMP2MMP9 | |
| SCHEMBL8913854 | 0.82 | MMP2 (0.57) | CTSLCTSSCTSKTP53MMP2 | |
| SCHEMBL8916336 | 0.81 | GAA (0.48) | MMP2MMP9ADAMTS4ITGB3ITGA2B | |
| SCHEMBL5189189 | 0.79 | MMP2 (0.79) | CTSLCTSSCTSKTP53MMP2 | |
| SCHEMBL7468716 | 0.79 | MMP2 (0.79) | CTSLCTSSCTSKTP53MMP2 | |
| SCHEMBL7460419 | 0.79 | MMP2 (0.79) | CTSLCTSSCTSKTP53MMP2 | |
| SCHEMBL8913773 | 0.78 | CTSL (0.48) | CTSLCTSSCTSKTP53MMP2 | |
| SCHEMBL8912753 | 0.77 | MMP1 (0.55) | MMP2MMP9ADAMTS4MMP1MMP3 | |
| SCHEMBL8915393 | 0.76 | ALDH1A1 (0.51) | MMP2MMP9ADAMTS4ITGB3ITGA2B | |
| SCHEMBL8914458 | 0.75 | P2RX7 (0.50) | MMP2MMP9MAPTMMP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5663174-A | ANTIINFLAMMATORY AGENTS, INHIBITOR OF KINASES, ANTIARTHRITIC AGENTS | PHARNO-WEDROPHARM GMBH (DE) | 1997-09-02 | — | — | US | disclosed |
| EP-0602028-B1 | AROMATIC SULFONAMIDE DERIVATIVES, THEIR USE AS ENZYME INHIBITORS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | PHARNO WEDROPHARM GMBH (DE) | 1996-01-17 | — | — | EP | disclosed |