Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B1 | P15538 | 1/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.35 |
| ▸ | EP300 | Q09472 | 9/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.32 |
| ▸ | FGFR4 | P22455 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8911516 | 0.95 | CYP11B1 (0.38) | CYP11B1CYP11B2SIRT2EP300KCNH2 | |
| SCHEMBL8912807 | 0.87 | CYP11B1 (0.44) | CYP11B1CYP11B2EP300KCNH2TSHR | |
| SCHEMBL8574886 | 0.87 | ALDH1A1 (0.41) | CYP11B1CYP11B2SIRT2 | |
| SCHEMBL8912511 | 0.82 | CYP11B1 (0.42) | CYP11B1CYP11B2SIRT2EP300KCNH2 | |
| SCHEMBL8911497 | 0.81 | PSMB5 (0.38) | CYP11B1CYP11B2SIRT2 | |
| SCHEMBL8911091 | 0.81 | ALDH1A1 (0.40) | CYP11B1CYP11B2SIRT2 | |
| SCHEMBL8911120 | 0.81 | NR1H2 (0.35) | CYP11B1CYP11B2 | |
| SCHEMBL8911137 | 0.80 | GCGR (0.36) | CYP11B1CYP11B2EP300CYP19A1 | |
| SCHEMBL8576519 | 0.77 | PSMB5 (0.42) | SIRT2 | |
| SCHEMBL8912796 | 0.76 | MEN1 (0.40) | CYP11B1CYP11B2SIRT2CYP19A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5650424-A | ANTIAGGLOMERANTS USING IMIDAZOLIDINDIONES | DR. KARL THOMAE GMBH (DE) | 1997-07-22 | — | — | US | disclosed |
| US-5478942-A | Antiinflammatory agents, antiagglomerants | KARL THOMAE GMBH (DE) | 1995-12-26 | — | — | US | disclosed |
| US-5276049-A | Treatment of thrombosis | DR. KARL THOMAE GMBH (DE) | 1994-01-04 | — | — | US | disclosed |