Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIN2B | Q13224 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | USP30 | Q70CQ3 | 2/20 | 0.40 |
| ▸ | MMEL1 | Q495T6 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.38 |
| ▸ | CD274 | Q9NZQ7 | 4/20 | 0.37 |
| ▸ | PDCD1 | Q15116 | 3/20 | 0.37 |
| ▸ | DRD4 | P21917 | 1/20 | 0.37 |
| ▸ | FKBP1A | P62942 | 3/20 | 0.37 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.37 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.36 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.36 |
| ▸ | OXTR | P30559 | 1/20 | 0.36 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8932026 | 0.75 | OXTR (0.37) | GRIN2BUSP30OXTRAVPR1A | |
| SCHEMBL7025809 | 0.74 | HPGD (0.59) | MEN1KMT2ADRD4 | |
| SCHEMBL7019918 | 0.72 | GAA (0.54) | GRIN2BMEN1KMT2A | |
| SCHEMBL2274911 | 0.71 | POLB (0.61) | POLBMMEL1MEN1KMT2AFKBP1A | |
| SCHEMBL2274909 | 0.71 | POLB (0.61) | POLBMMEL1MEN1KMT2AFKBP1A | |
| SCHEMBL7014933 | 0.67 | TRPA1 (0.53) | MEN1KMT2ADRD4 | |
| SCHEMBL6095418 | 0.67 | GRIN2B (0.42) | GRIN2BDRD4HCRTR1HCRTR2 | |
| SCHEMBL7020356 | 0.67 | MAPT (0.47) | — | |
| SCHEMBL11026079 | 0.67 | FKBP1A (0.56) | POLBMMEL1MEN1KMT2AFKBP1A | |
| SCHEMBL7020541 | 0.67 | TRPA1 (0.50) | MEN1KMT2ADRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5612360-A | AROMATIC N-HETEROCYCLIC COMPOUNDS AS HYPOTENSIVE AGENTS WITH ACID GROUPS, SULFONYLCARBOXAMIDES OR TETRAZOLE GROUPS | ELI LILLY AND COMPANY (US) | 1997-03-18 | — | — | US | disclosed |
| US-5569768-A | USEFUL IN TREATING HYPERTENSION, CONGESTIVE HEART FAILURE, GLAUCOMA AND RENAL INSUFFICIENCY | ELI LILLY AND COMPANY (US) | 1996-10-29 | — | — | US | disclosed |
| US-5556981-A | Angiotensin II antagonist intermediates | ELI LILLY AND COMPANY (US) | 1996-09-17 | — | — | US | disclosed |
| EP-0574174-A2 | Angiotensin II antagonists | ELI LILLY AND COMPANY (US) | 1993-12-15 | — | — | EP | disclosed |